2024

Bat humoral immunity and its role in viral pathogenesis, transmission, and zoonosis. Roffler AA, Maurer DP, Lunn TJ, Sironen T, Forbes KM, Schmidt AG. Front Immunol. 2024 Aug 2;15:1269760. doi: 10.3389/fimmu.2024.1269760.

B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S. Jacob-Dolan C, Lifton M, Powers OC, Miller J, Hachmann NP, Vu M, Surve N, Mazurek CR, Fisher JL, Rodrigues S, Patio RC, Anand T, Le Gars M, Sadoff J, Schmidt AG, Barouch DH. iScience. 2024 Apr 9;27(5):109716. doi: 10.1016/j.isci.2024.109716.

Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses. Ray R, Nait Mohamed FA, Maurer DP, Huang J, Alpay BA, Ronsard L, Xie Z, Han J, Fernandez-Quintero M, Phan QA, Ursin RL, Vu M, Kirsch KH, Prum T, Rosado VC, Bracamonte-Moreno T, Okonkwo V, Bals J, McCarthy C, Nair U, Kanekiyo M, Ward AB, Schmidt AG, Batista FD, Lingwood D. Immunity. 2024. Epub 20240418. doi: 10.1016/j.immuni.2024.03.022.

A modular platform to display multiple hemagglutinin subtypes on a single immunogen. Thornlow Lamson D, Nait Mohamed F, Vu M, Maurer DP, Ronsard L, Lingwood D, Schmidt AG. eLife 2024. https://doi.org/10.7554/eLife.97364.1

Antigenic drift expands viral escape pathways from imprinted host humoral immunity. Maurer DP, Vu M, Schmidt AG. bioRxiv. 2024. https://doi.org/10.1101/2024.03.20.585891

Lupus-associated innate receptors drive extrafollicular evolution of autoreactive B cells. Zhu DY, Maurer DP, Castrillon C, Deng Y, Mohamed FAN, Ma M, Schmidt AG, Lingwood D, Carroll MC. bioRxiv. 2024. Epub 20240109. doi: 10.1101/2024.01.09.574739. PMID: 38260501.

Mucosal vaccine-induced cross-reactive CD8(+) T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection. Ying B, Darling TL, Desai P, Liang CY, Dmitriev IP, Soudani N, Bricker T, Kashentseva EA, Harastani H, Raju S, Liu M, Schmidt AG, Curiel DT, Boon ACM, Diamond MS. Nat Immunol. 2024;25(3):537-51. Epub 20240209. doi: 10.1038/s41590-024-01743-x. PMID: 38337035.

Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds. Wamhoff EC, Ronsard L, Feldman J, Knappe GA, Hauser BM, Romanov A, Case JB, Sanapala S, Lam EC, Denis KJS, Boucau J, Barczak AK, Balazs AB, Diamond MS, Schmidt AG, Lingwood D, Bathe M. Nat Commun. 2024;15(1):795. Epub 20240130. doi: 10.1038/s41467-024-44869-0. PMID: 38291019.

Heterologous Sarbecovirus Receptor Binding Domains as Scaffolds for SARS-CoV-2 Receptor Binding Motif Presentation. Hauser BM, Sangesland M, Lam EC, St Denis KJ, Sheehan ML, Vu ML, Cheng AH, Sordilla S, Lamson DT, Almawi AW, Balazs AB, Lingwood D, Schmidt AG. ACS Infect Dis. 2024;10(2):553-61. Epub 20240128. doi: 10.1021/acsinfecdis.3c00483.PMID: 38281136.

2023

Mechanisms that promote the evolution of cross-reactive antibodies upon vaccination with designed influenza immunogens. Yang L, Caradonna TM, Schmidt AG, Chakraborty AK.Cell Rep. 2023 Mar 28;42(3):112160. doi: 10.1016/j.celrep.2023.112160. Epub 2023 Mar 2.PMID: 36867533

Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. Nanishi E, Borriello F, Seo HS, O'Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O.NPJ Vaccines. 2023 Feb 14;8(1):18. doi: 10.1038/s41541-023-00610-4.PMID: 36788219

Lectin Fingerprinting Distinguishes Antibody Neutralization in SARS-CoV-2. Wuo MG, Dugan AE, Halim M, Hauser BM, Feldman J, Caradonna TM, Zhang S, Pepi LE, Atyeo C, Fischinger S, Alter G, Garcia-Beltran WF, Azadi P, Hung D, Schmidt AG, Kiessling LL. ACS Cent Sci. 2023;9(5):947-56. Epub 20230510. doi: 10.1021/acscentsci.2c01471. PMID: 37252360

SARS-CoV-2 Serosurveys: How Antigen, Isotype and Threshold Choices Affect the Outcome. Binder RA, Fujimori GF, Forconi CS, Reed GW, Silva LS, Lakshmi PS, Higgins A, Cincotta L, Dutta P, Salive MC, Mangolds V, Anya O, Calvo Calle JM, Nixon T, Tang Q, Wessolossky M, Wang Y, Ritacco DA, Bly CS, Fischinger S, Atyeo C, Oluoch PO, Odwar B, Bailey JA, Maldonado-Contreras A, Haran JP, Schmidt AG, Cavacini L, Alter G, Moormann AM.J Infect Dis. 2023 Feb 1;227(3):371-380. doi: 10.1093/infdis/jiac431.PMID: 36314635

Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody Phillips AM, Maurer DP, Brooks C, Dupic T, Schmidt AG, Desai MM. Elife. 2023 Jan 10;12. PMID: 36625542, https://doi.org/e83628

Invasion of the germinal centers Maurer DP, Schmidt AG. Cell. 2023 Jan 5;186(1):12-14. PMID: 36608649, https://doi.org/10.1016/j.cell.2022.12.023

2022

An epitope-enriched immunogen expands responses to a conserved viral site Caradonna TM, Ronsard L, Yousif AS, Windsor IW, Hecht R, Bracamonte-Moreno T, Roffler AA, Maron MJ, Maurer DP, Feldman J, Marchiori E, Barnes RM, Rohrer D, Lonberg N, Oguin TH 3rd, Sempowski GD, Kepler TB, Kuraoka M, Lingwood D, Schmidt AG. Cell Rep. 2022 Nov 8;41(6):111628. PMID: 36351401, PMCID: PMC9883670, https://doi.org/10.1016/j.celrep.2022.111628

Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses Tas JMJ, Koo JH, Lin YC, Xie Z, Steichen JM, Jackson AM, Hauser BM, Wang X, Cottrell CA, Torres JL, Warner JE, Kirsch KH, Weldon SR, Groschel B, Nogal B, Ozorowski G, Bangaru S, Phelps N, Adachi Y, Eskandarzadeh S, Kubitz M, Burton DR, Lingwood D, Schmidt AG, Nair U, Ward AB, Schief WR, Batista FD.  Immunity. 2022 Oct 11;55(10):1856-11871.e6. PMID: 35987201, PMCID: PMC9350677, https://doi.org/10.1016/j.immuni.2022.07.020

Cross-reactive SARS-CoV-2 epitope targeted across donors informs immunogen design Hauser BM, Feldman J, Sangesland M, Ronsard L, St Denis KJ, Sheehan ML, Cao Y, Boucau J, Windsor IW, Cheng AH, Vu ML, Cardoso MR, Kannegieter T, Balazs AB, Lingwood D, Garcia-Beltran WF, Schmidt AG.Cell Rep Med. 2022 Dec 20;3(12):100834. doi: 10.1016/j.xcrm.2022.100834. Epub 2022 Nov 15.PMID: 36423634

Humoral responses to the SARS-CoV-2 spike and receptor binding domain in context of pre-existing immunity confer broad sarbecovirus neutralization Hauser BM, Sangesland M, Lam EC, Feldman J, Balazs AB, Lingwood D, Schmidt AG. Front Immunol. 2022;13:902260. PMID: 35990628, PMCID: PMC9386501, https://doi.org/902260

Durability of Heterologous and Homologous COVID-19 Vaccine Boosts Tan CS, Collier AY, Yu J, Liu J, Chandrashekar A, McMahan K, Jacob-Dolan C, He X, Roy V, Hauser BM, Munt JE, Mallory ML, Mattocks M, Powers JM, Meganck RM, Rowe M, Hemond R, Bondzie EA, Jaegle KH, Baric RS, Schmidt AG, Alter G, Le Gars M, Sadoff J, Barouch DH. JAMA Netw Open. 2022 Aug 1;5(8):e2226335. PMID: 35947380, PMCID: PMC9366542, https://doi.org/e2226335

Rotavirus VP4 Epitope of a Broadly Neutralizing Human Antibody Defined by Its Structure Bound with an Attenuated-Strain Virion Jenni S, Li Z, Wang Y, Bessey T, Salgado EN, Schmidt AG, Greenberg HB, Jiang B, Harrison SC. J Virol. 2022 Aug 24;96(16):e0062722. PMID: 35924923, PMCID: PMC9400500, https://doi.org/e00627-22

Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting Hauser BM, Sangesland M, St Denis KJ, Lam EC, Case JB, Windsor IW, Feldman J, Caradonna TM, Kannegieter T, Diamond MS, Balazs AB, Lingwood D, Schmidt AG. Cell Rep. 2022 Mar 22;38(12):110561. PMID: 35303475, PMCID: PMC8898741, https://doi.org/10.1016/j.celrep.2022.110561

Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells Amraei R, Xia C, Olejnik J, White MR, Napoleon MA, Lotfollahzadeh S, Hauser BM, Schmidt AG, Chitalia V, Mühlberger E, Costello CE, Rahimi N. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6). PMID: 35078919, PMCID: PMC8833221, https://doi.org/e2113874119

mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant Garcia-Beltran WF, St Denis KJ, Hoelzemer A, Lam EC, Nitido AD, Sheehan ML, Berrios C, Ofoman O, Chang CC, Hauser BM, Feldman J, Roederer AL, Gregory DJ, Poznansky MC, Schmidt AG, Iafrate AJ, Naranbhai V, Balazs AB. Cell. 2022 Feb 3;185(3):457-466.e4. PMID: 34995482, PMCID: PMC8733787, https://doi.org/10.1016/j.cell.2021.12.033

An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Cavazzoni CB, Brook B, Barman S, Chen J, Diray-Arce J, Doss-Gollin S, De Leon M, Prevost-Reilly A, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Sage PT, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ. Sci Transl Med. 2022 Jan 26;14(629):eabj5305. PMID: 34783582, https://doi.org/10.1126/scitranslmed.abj5305

Preferential expansion upon boosting of cross-reactive “pre-existing” switched memory B cells that recognize the SARS-CoV-2 Omicron variant Spike protein Perugino, C. A., Liu, H., Feldman, J., Hauser, B. M., Jacob-Dolan, C., Nathan, A., Zhou, Z., Kaseke, C., Tano-Menka, R., Getz, M. A., Senjobe, F., Berrios, C., Ofoman, O., Lemieux, J. E., Goldberg, M. B., Nundel, K., Moormann, A., Marshak-Rothstein, A., Iafrate, J. A., Gaiha, G., Charles, R., Balazs, A. B., Naranbhai, V., Schmidt, A. G. & Pillai, S. Preferential expansion upon boosting of cross-reactive “pre-existing” switched memory B cells that recognize the SARS-CoV-2 Omicron variant Spike protein. Preprint at https://doi.org/10.1101/2021.12.30.21268554 (2022)

2021

Protein engineering strategies for rational immunogen design Caradonna TM, Schmidt AG. Protein engineering strategies for rational immunogen design. NPJ Vaccines. 2021 Dec 17;6(1):154.

mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant Garcia-Beltran WF, St Denis KJ, Hoelzemer A, Lam EC, Nitido AD, Sheehan ML, Berrios C, Ofoman O, Chang CC, Hauser BM, Feldman J, Roederer AL, Gregory DJ, Poznansky MC, Schmidt AG, Iafrate AJ, Naranbhai V, Balazs AB. mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant. Cell. 2022 Feb 3;185(3):457-466.e4. doi: 10.1016/j.cell.2021.12.033. Epub 2022 Jan 6. PMID: 34995482; PMCID: PMC8733787. [Preprint previously available on medRxiv]

Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses Feldman J, Bals J, Altomare CG, St Denis K, Lam EC, Hauser BM, Ronsard L, Sangesland M, Moreno TB, Okonkwo V, Hartojo N, Balazs AB, Bajic G, Lingwood D, Schmidt AG. Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses. Sci Immunol. 2021 Dec 10;6(66):eabl5842.

An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor-binding domain vaccine in aged mice Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Cavazzoni CB, Brook B, Barman S, Chen J, Diray-Arce J, Doss-Gollin S, De Leon M, Prevost-Reilly A, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Sage PT, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ. An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor-binding domain vaccine in aged mice. Sci Transl Med. 2021 Nov 16:eabj5305.

Rapid generation of potent antibodies by autonomous hypermutation in yeast Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Hu VJ, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC. Rapid generation of potent antibodies by autonomous hypermutation in yeast. Nat Chem Biol. 2021 Oct;17(10):1057-1064.

Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization. Thornlow DN, Macintyre AN, Oguin TH, Karlsson AB, Stover EL, Lynch HE, Sempowski GD, Schmidt AG. Front Immunol. 2021 Oct 7;12:737973.

Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike. Tong P, Gautam A, Windsor IW, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Storm N, Malsick LE, Honko AN, Lelis FJN, Habibi S, Jenni S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DR. Cell. 2021 Sep 16;184(19):4969-4980.e15.

An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates. Zabaleta N, Dai W, Bhatt U, Hérate C, Maisonnasse P, Chichester JA, Sanmiguel J, Estelien R, Michalson KT, Diop C, Maciorowski D, Dereuddre-Bosquet N, Cavarelli M, Gallouët AS, Naninck T, Kahlaoui N, Lemaitre J, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Contreras V, Marlin R, Tsong Fang RH, Chapon C, van der Werf S, Zinn E, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Le Grand R, Vandenberghe LH. Cell Host Microbe. 2021 Sep 8;29(9):1437-1453.e8.

In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies. Li D, Edwards RJ, Manne K, Martinez DR, Schäfer A, Alam SM, Wiehe K, Lu X, Parks R, Sutherland LL, Oguin TH 3rd, McDanal C, Perez LG, Mansouri K, Gobeil SMC, Janowska K, Stalls V, Kopp M, Cai F, Lee E, Foulger A, Hernandez GE, Sanzone A, Tilahun K, Jiang C, Tse LV, Bock KW, Minai M, Nagata BM, Cronin K, Gee-Lai V, Deyton M, Barr M, Von Holle T, Macintyre AN, Stover E, Feldman J, Hauser BM, Caradonna TM, Scobey TD, Rountree W, Wang Y, Moody MA, Cain DW, DeMarco CT, Denny TN, Woods CW, Petzold EW, Schmidt AG, Teng IT, Zhou T, Kwong PD, Mascola JR, Graham BS, Moore IN, Seder R, Andersen H, Lewis MG, Montefiori DC, Sempowski GD, Baric RS, Acharya P, Haynes BF, Saunders KO. Cell. 2021 Aug 5;184(16):4203-4219.e32.

CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2. Amraei R, Yin W, Napoleon MA, Suder EL, Berrigan J, Zhao Q, Olejnik J, Chandler KB, Xia C, Feldman J, Hauser BM, Caradonna TM, Schmidt AG, Gummuluru S, Mühlberger E, Chitalia V, Costello CE, Rahimi N. ACS Cent Sci. 2021 Jul 28;7(7):1156-1165.

Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women. Collier AY, McMahan K, Yu J, Tostanoski LH, Aguayo R, Ansel J, Chandrashekar A, Patel S, Apraku Bondzie E, Sellers D, Barrett J, Sanborn O, Wan H, Chang A, Anioke T, Nkolola J, Bradshaw C, Jacob-Dolan C, Feldman J, Gebre M, Borducchi EN, Liu J, Schmidt AG, Suscovich T, Linde C, Alter G, Hacker MR, Barouch DH. JAMA. 2021 Jun 15;325(23):2370-2380.

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Garcia-Beltran WF, Lam EC, St Denis K, Nitido AD, Garcia ZH, Hauser BM, Feldman J, Pavlovic MN, Gregory DJ, Poznansky MC, Sigal A, Schmidt AG, Iafrate AJ, Naranbhai V, Balazs AB. Cell. 2021;184(9):2372-83 e9.

Coronavirus-Specific Antibody Cross Reactivity in Rhesus Macaques Following SARS-CoV-2 Vaccination and Infection. Jacob-Dolan C, Feldman J, McMahan K, Yu J, Zahn R, Wegmann F, Schuitemaker H, Schmidt AG, Barouch DH. J Virol. 2021 Mar 10;95(11):e00117-21.

COVID-19-neutralizing antibodies predict disease severity and survival. Garcia-Beltran WF, Lam EC, Astudillo MG, Yang D, Miller TE, Feldman J, Hauser BM, Caradonna TM, Clayton KL, Nitido AD, Murali MR, Alter G, Charles RC, Dighe A, Branda JA, Lennerz JK, Lingwood D, Schmidt AG, Iafrate AJ, Balazs AB. Cell. 2021 Jan 21;184(2):476-488.e11.

2020

Zohar T, Loos C, Fischinger S, Atyeo C, Wang C, Slein MD, Burke J, Yu J, Feldman J, Hauser BM, Caradonna T, Schmidt AG, Cai Y, Streeck H, Ryan ET, Barouch DH, Charles RC, Lauffenburger DA, Alter G. Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality. Cell. 2020;183(6):1508-19 e12.

Yu J, Tostanoski LH, Peter L, Mercado NB, McMahan K, Mahrokhian SH, Nkolola JP, Liu J, Li Z, Chandrashekar A, Martinez DR, Loos C, Atyeo C, Fischinger S, Burke JS, Slein MD, Chen Y, Zuiani A, Lelis FJN, Travers M, Habibi S, Pessaint L, Van Ry A, Blade K, Brown R, Cook A, Finneyfrock B, Dodson A, Teow E, Velasco J, Zahn R, Wegmann F, Bondzie EA, Dagotto G, Gebre MS, He X, Jacob-Dolan C, Kirilova M, Kordana N, Lin Z, Maxfield LF, Nampanya F, Nityanandam R, Ventura JD, Wan H, Cai Y, Chen B, Schmidt AG, Wesemann DR, Baric RS, Alter G, Andersen H, Lewis MG, Barouch DH. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science. 2020;369(6505):806-11.

Tostanoski LH, Wegmann F, Martinot AJ, Loos C, McMahan K, Mercado NB, Yu J, Chan CN, Bondoc S, Starke CE, Nekorchuk M, Busman-Sahay K, Piedra-Mora C, Wrijil LM, Ducat S, Custers J, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Jacob-Dolan C, Lin Z, Mahrokhian SH, Nampanya F, Nityanandam R, Pessaint L, Porto M, Ali V, Benetiene D, Tevi K, Andersen H, Lewis MG, Schmidt AG, Lauffenburger DA, Alter G, Estes JD, Schuitemaker H, Zahn R, Barouch DH. Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters. Nat Med. 2020;26(11):1694-700.

Miller TE, Garcia Beltran WF, Bard AZ, Gogakos T, Anahtar MN, Astudillo MG, Yang D, Thierauf J, Fisch AS, Mahowald GK, Fitzpatrick MJ, Nardi V, Feldman J, Hauser BM, Caradonna TM, Marble HD, Ritterhouse LL, Turbett SE, Batten J, Georgantas NZ, Alter G, Schmidt AG, Harris JB, Gelfand JA, Poznansky MC, Bernstein BE, Louis DN, Dighe A, Charles RC, Ryan ET, Branda JA, Pierce VM, Murali MR, Iafrate AJ, Rosenberg ES, Lennerz JK. Clinical sensitivity and interpretation of PCR and serological COVID-19 diagnostics for patients presenting to the hospital. FASEB J. 2020;34(10):13877-84.

Naranbhai V, Chang CC, Beltran WFG, Miller TE, Astudillo MG, Villalba JA, Yang D, Gelfand J, Bernstein BE, Feldman J, Hauser BM, Caradonna TM, Alter G, Murali MR, Jasrasaria R, Quinlan J, Xerras DC, Betancourt JR, Louis DN, Schmidt AG, Lennerz J, Poznansky MC, Iafrate AJ. High Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chelsea, Massachusetts. J Infect Dis. 2020;222(12):1955-9.

Norman M, Gilboa T, Ogata AF, Maley AM, Cohen L, Busch EL, Lazarovits R, Mao CP, Cai Y, Zhang J, Feldman JE, Hauser BM, Caradonna TM, Chen B, Schmidt AG, Alter G, Charles RC, Ryan ET, Walt DR. Ultrasensitive high-resolution profiling of early seroconversion in patients with COVID-19. Nat Biomed Eng. 2020;4(12):1180-7.

Mercado NB, Zahn R, Wegmann F, Loos C, Chandrashekar A, Yu J, Liu J, Peter L, McMahan K, Tostanoski LH, He X, Martinez DR, Rutten L, Bos R, van Manen D, Vellinga J, Custers J, Langedijk JP, Kwaks T, Bakkers MJG, Zuijdgeest D, Rosendahl Huber SK, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Hoffman E, Jacob-Dolan C, Kirilova M, Li Z, Lin Z, Mahrokhian SH, Maxfield LF, Nampanya F, Nityanandam R, Nkolola JP, Patel S, Ventura JD, Verrington K, Wan H, Pessaint L, Van Ry A, Blade K, Strasbaugh A, Cabus M, Brown R, Cook A, Zouantchangadou S, Teow E, Andersen H, Lewis MG, Cai Y, Chen B, Schmidt AG, Reeves RK, Baric RS, Lauffenburger DA, Alter G, Stoffels P, Mammen M, Van Hoof J, Schuitemaker H, Barouch DH. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature. 2020;586(7830):583-8.

Kaneko N, Kuo HH, Boucau J, Farmer JR, Allard-Chamard H, Mahajan VS, Piechocka-Trocha A, Lefteri K, Osborn M, Bals J, Bartsch YC, Bonheur N, Caradonna TM, Chevalier J, Chowdhury F, Diefenbach TJ, Einkauf K, Fallon J, Feldman J, Finn KK, Garcia-Broncano P, Hartana CA, Hauser BM, Jiang C, Kaplonek P, Karpell M, Koscher EC, Lian X, Liu H, Liu J, Ly NL, Michell AR, Rassadkina Y, Seiger K, Sessa L, Shin S, Singh N, Sun W, Sun X, Ticheli HJ, Waring MT, Zhu AL, Alter G, Li JZ, Lingwood D, Schmidt AG, Lichterfeld M, Walker BD, Yu XG, Padera RF, Jr., Pillai S, Massachusetts Consortium on Pathogen Readiness Specimen Working G. Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19. Cell. 2020;183(1):143-57 e13.

Iyer AS, Jones FK, Nodoushani A, Kelly M, Becker M, Slater D, Mills R, Teng E, Kamruzzaman M, Garcia-Beltran WF, Astudillo M, Yang D, Miller TE, Oliver E, Fischinger S, Atyeo C, Iafrate AJ, Calderwood SB, Lauer SA, Yu J, Li Z, Feldman J, Hauser BM, Caradonna TM, Branda JA, Turbett SE, LaRocque RC, Mellon G, Barouch DH, Schmidt AG, Azman AS, Alter G, Ryan ET, Harris JB, Charles RC. Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients. Sci Immunol. 2020;5(52).

Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts P, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Cell. 2020;183(4):1043-57 e15.

Chen Y, Zuiani A, Fischinger S, Mullur J, Atyeo C, Travers M, Lelis FJN, Pullen KM, Martin H, Tong P, Gautam A, Habibi S, Bensko J, Gakpo D, Feldman J, Hauser BM, Caradonna TM, Cai Y, Burke JS, Lin J, Lederer JA, Lam EC, Lavine CL, Seaman MS, Chen B, Schmidt AG, Balazs AB, Lauffenburger DA, Alter G, Wesemann DR. Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production. Cell. 2020;183(6):1496-507 e16. Epub 2020/11/11.

Chandrashekar A, Liu J, Martinot AJ, McMahan K, Mercado NB, Peter L, Tostanoski LH, Yu J, Maliga Z, Nekorchuk M, Busman-Sahay K, Terry M, Wrijil LM, Ducat S, Martinez DR, Atyeo C, Fischinger S, Burke JS, Slein MD, Pessaint L, Van Ry A, Greenhouse J, Taylor T, Blade K, Cook A, Finneyfrock B, Brown R, Teow E, Velasco J, Zahn R, Wegmann F, Abbink P, Bondzie EA, Dagotto G, Gebre MS, He X, Jacob-Dolan C, Kordana N, Li Z, Lifton MA, Mahrokhian SH, Maxfield LF, Nityanandam R, Nkolola JP, Schmidt AG, Miller AD, Baric RS, Alter G, Sorger PK, Estes JD, Andersen H, Lewis MG, Barouch DH. SARS-CoV-2 infection protects against rechallenge in rhesus macaques. Science. 2020;369(6505):812-7.

Atyeo C, Fischinger S, Zohar T, Slein MD, Burke J, Loos C, McCulloch DJ, Newman KL, Wolf C, Yu J, Shuey K, Feldman J, Hauser BM, Caradonna T, Schmidt AG, Suscovich TJ, Linde C, Cai Y, Barouch D, Ryan ET, Charles RC, Lauffenburger D, Chu H, Alter G. Distinct Early Serological Signatures Track with SARS-CoV-2 Survival. Immunity. 2020;53(3):524-32 e4.

Yu J, Tostanoski LH, Peter L, Mercado NB, McMahan K, Mahrokhian SH, Nkolola JP, Liu J, Li Z, Chandrashekar A, Martinez DR, Loos C, Atyeo C, Fischinger S, Burke JS, Slein MD, Chen Y, Zuiani A, Lelis FJN, Travers M, Habibi S, Pessaint L, Van Ry A, Blade K, Brown R, Cook A, Finneyfrock B, Dodson A, Teow E, Velasco J, Zahn R, Wegmann F, Bondzie EA, Dagotto G, Gebre MS, He X, Jacob-Dolan C, Kirilova M, Kordana N, Lin Z, Maxfield LF, Nampanya F, Nityanandam R, Ventura JD, Wan H, Cai Y, Chen B, Schmidt AG, Wesemann DR, Baric RS, Alter G, Andersen H, Lewis MG, Barouch DH. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science. 2020 Aug 14;369(6505):806-811. doi: 10.1126/science.abc6284.

Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH 2nd, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J; HCA Lung Biological Network. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. 2020 May 28;181(5):1016-1035.e19.

Joshi VR, Newman RM, Pack ML, Power KA, Munro JB, Okawa K, Madani N, Sodroski JG, Schmidt AG, Allen TM. Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein. PLoS Pathog. 2020 May;16(5):e1008577.

Goran Bajic, Max J. Maron, Timothy M. Caradonna, Ming Tian, Adam Mermelstein, Daniela Fera, Garnett Kelsoe, Masayuki Kuraoka, and Aaron G. Schmidt. Structure-Guided Molecular Grafting of a Complex Broadly Neutralizing Viral Epitope. ACS Infectious Diseases, ACS Infectious Diseases, April 4, 2020. DOI: 10.1021/acsinfecdis.0c00008

2019

Watanabe A, Su KY, Kuraoka M, Yang G, Reynolds AE, Schmidt AG, Harrison SC, Haynes BF, St Clair EW, Kelsoe G. Self-tolerance curtails the B cell repertoire to microbial epitopes. JCI Insight. 2019 May 16;4(10). doi: 10.1172/jci.insight.122551. eCollection 2019 May 16. 

McCarthy, K.R., Raymond, D.D., Do, K.T., Schmidt, A.G., Harrison, S.C.  Affinity maturation in a human humoral response to influenza hemagglutinin.  PNAS 116 (52):  26745-51 (2019)

Goran Bajic and Max J. Maron, Yu Adachi, Taishi Onodera, Kevin R. McCarthy, Charles E. McGee, Gregory D. Sempowski, Yoshimasa Takahashi, Garnett Kelsoe, Masayuki Kuraoka, Aaron G. Schmidt (2019) Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope. Cell Host & Microbe. 1931-3128.

Akiko Watanabe and Kevin R. McCarthy, Masayuki Kuraoka, Aaron G. Schmidt, Yu Adachi, Taishi Onodera, Keisuke Tonouchi, Timothy M. Caradonna, Goran Bajic, Shengli Song, Charles E. McGee, Gregory D. Sempowski, Feng Feng, Patricia Urick, Thomas B. Kepler, Yoshimasa Takahashi, Stephen C. Harrison, Garnett Kelsoe (2019) Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism. Cell. 177, 5: 1124-1135.

Goran Bajic, Cees E. van der Poel, Masayuki Kuraoka, Aaron G. Schmidt, Michael C. Carroll, Garnett Kelsoe & Stephen C. Harrison. (2019) Autoreactivity Profiles of Influenza Hemagglutinin Broadly Neutralizing Antibodies. Scientific Reports 9, 3492

2018

McCarthy KR, Watanabe A, Kuraoka M, Do KT, McGee CE, Sempowski GD, Schmidt AG, Kelsoe G, Harrison SC (2018) Human Memory B cells that Cross-React with Group 1 and Group 2 Influenza A Viruses. Immunity. 48: 174-184

Raymond DD, Bajic G, Ferdman J, Suphaphiphat P, Settembre E, Moody MA, Schmidt AG, Harrison SC. (2018) Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody. PNAS 17154711: 1-6.

Wang, Bo, Brandon J. DeKosky, Morgan R. Timm, Jiwon Lee, Erica Normandin, John Misasi, Rui Kong, Jonathan R. McDaniel, George Delidakis, Kendra E. Leigh, Thomas Niezold, Chang W. Choi, Elise G. Viox, Ahmed Fahad, Alberto Cagigi, Aurélie Ploquin, Kwanyee Leung, Eun Sung Yang, Wing-Pui Kong, William N. Voss, Aaron G. Schmidt, M. Anthony Moody, David R. Ambrozak, Amy R. Henry, Farida Laboune, Julie E. Ledgerwood, Barney S. Graham, Mark Connors, Daniel C. Douek, Nancy J. Sullivan, Andrew D. Ellington, John R. Mascola, and George Georgiou. 2018. 'Functional interrogation and mining of natively paired human VH:VL antibody repertoires', Nature Biotechnology.

2017

Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff N (2017) CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. Journal of Molecular Biology. 429: 1829-1839.

2016

Raymond DD, Stewart S, Lee J, Ferdman J, Bajic G, Do KT, Ernandes MJ, Suphaphiphat P, Settembre EC, Dormitzer PR, Del Giudice G, Finco O, Kang TH, Ippolito GC, Georgiou G, Kepler TB, Haynes BF, Moody MA,  Liao H-X, Schmidt AG, Harrison SC (2016) Influenza immunization elicits hemagglutinin receptor-site antibodies specific for an egg-adapted vaccine strain. Nature Medicine. 10.1038: 1-7.

Clark MJ, Miduturu C, Schmidt AG, Zhu X, Pitts JD, Wang J, Potisopon S, Zhang J, Wojciechowski A, Hann Chu JJ, Gray NS, Yang PL. (2016) GNF-2 Inhibits Dengue Virus by Targeting Abl Kinases and the Viral E Protein. Cell Chemical Biology. 23 443-52.

Kuraoka M, Schmidt AG, Nojima, T, Feng F, Watanabe A, Kitamura D, Harrison SC, Kepler TB and Kelsoe G (2016) B-cell selection in germinal centers elicited by complex antigens. Immunity, 44 1-11.

2015

Schmidt, A.G., Do, T.K., McCarthy, K.M., Kepler, T.B., Liao, H-X., Moody, M.A., Haynes, B.F., Harrison, S.C. Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site. Cell Reports 13: 2842-2850 (2015).

Schmidt, A.G., Therkelsen, M.D., Stewart, S., Kepler, T.B., Liao, H-X., Moody, M.A., Haynes, B.F., Harrison, S.C. Viral Receptor-Binding Site Antibodies with Diverse Germline Origins. Cell 161: 1026-1034 (2015).

2014

Chao, L.H., Klein, D.E., Schmidt, A.G., Pena, J.M., Harrison, S.C. Sequential conformational rearrangements in flavivirus membrane fusion. eLIFE 3:e04389: 1-21 (2014)

Xu, H., Schmidt, A.G., O'Donnell, T., Therkelsen, M.D., Kepler, T.B., Moody, M.A., Haynes, B.F., Liao, H-X., Harrison, S.C., Shaw, D.E. Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage. Proteins 390: 771-780 (2014).

Fera, D., Schmidt, A.G., Haynes, B.F., Gao, F., Liao, H-X., Kepler, T.B., Harrison, S.C. Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains. PNAS 111(28): 10275-80 (2014). 

2013

McCarthy KM, Schmidt AG, Kirmaier A, Wyand AL, Newman RM, Johnson WE. (2013) Gain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α Specificity. PLoS Pathog 9(5): e1003352.

Schmidt, A.G., Xu, H., Khan, A.R., O'Donnell, T., Khurana, S., King, L.R., Manischewitz, J., Golding, H., Suphaphiphat, P., Carfi, A., Settembre, E.C., Dormitzer, P.D., Kepler, T.B., Zhang, R., Moody, M.A., Haynes. B.F., Liao, H-X., Shaw, D.E., Harrison, S.C. Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. PNAS 110 (1): 264-269 (2013).

2012

Schmidt AG, Lee K, Yang PL and Harrison SC (2012) Small-molecule inhibitors of dengue-virus entry. PLoS Pathogens 8 (4): 1-10.

2010

Schmidt AG, Yang PL and Harrison SC (2010) Peptide inhibitors of flavivirus entry derived from the E protein stem. J Virol. 2010 Dec; 84 (24):12549-54.

Schmidt AG, Yang PL, and Harrison SC (2010). Peptide Inhibitors of Dengue-Virus Entry Target a Late Stage Fusion Intermediate. PLoS Pathogens (6 ) 4.

2007

Brockman MA, Schneidewind A, Lahaie M, Schmidt A, Miura T, Desouza I, Ryvkin F, Derdeyn CA, Allen S, Hunter E, Mulenga J, Goepfert PA, Walker BD, Allen TM. (2007) Escape and compensation from early HLA-B57-mediated CTL pressure on HIV-1 Gag alters capsid interactions with cyclophilin A. J Virol; 81 (22): 12608-18.